Frontiers | What is Life?
In the twentieth century, life was defined as cells that self-replicate, metabolize, and are open for mutations, without which genetic information would remain unchangeable, and evolution would be impossible. Current definitions of life derive from statistical mechanics, physics, and chemistry of the twentieth century in which life is considered to function machine like, ignoring a central role of communication. Recent observations show that context-dependent meaningful communication and network formation (and control) are central to all life forms.Evolutionary relevant new nucleotide sequences now appear to have originated from social agents such as viruses, their parasitic relatives, and related RNA networks, not from errors. By applying the known features of natural languages and communication, a new twenty-first century definition of life can be reached in which communicative interactions are central to all processes of life.A new definition of life must integrate the current empirical knowledge about interactions between cells, viruses, and RNA networks to provide a better explanatory power than the twentieth century narrative. Scientifically, the first half of the twentieth century was the most successful period for empirically based sciences.With the rise of molecular biology, and genetics, he adapted the code-metaphor to describe various features of the genetic code as the result of a molecular ensemble of nucleotides that underlies statistical fluctuations. These are the consequences out of thermodynamics of living systems. Schroedinger's book, “What is Life?” and his suggestion therein, “Life is physics and chemistry,” became one of the most influential works of the twentieth century.